Protein structure: Proton-pumping oxidases
نویسندگان
چکیده
The crystal structures of two cytochrome c oxidases, one bacterial and one mammalian, offer insights into their roles in oxygen chemistry and as proton pumps.
منابع مشابه
Computational investigation of oxygen reduction and proton pumping in cbb3-type Cytochrome c Oxidases
Heme-copper oxidases terminate the respiratory chain in many eukaryotes and prokaryotes as the final electron acceptors. They catalyze the reduction of molecular oxygen to water, and conserve the free-energy by proton pumping across the inner mitochondrial membrane or plasma membrane of bacteria. This leads to the generation of an electrochemical gradient across the membrane, which is utilized ...
متن کاملCytochrome cbb3 of Thioalkalivibrio is a Na+-pumping cytochrome oxidase.
Cytochrome c oxidases (Coxs) are the basic energy transducers in the respiratory chain of the majority of aerobic organisms. Coxs studied to date are redox-driven proton-pumping enzymes belonging to one of three subfamilies: A-, B-, and C-type oxidases. The C-type oxidases (cbb3 cytochromes), which are widespread among pathogenic bacteria, are the least understood. In particular, the proton-pum...
متن کاملMechanistic stoichiometry of proton translocation by cytochrome cbb3.
Cytochrome cbb(3) belongs to the superfamily of respiratory heme-copper oxidases that couple the reduction of molecular oxygen to proton translocation across the bacterial or mitochondrial membrane. The cbb(3)-type enzymes are found only in bacteria, and are both structurally and functionally the most distant from their mitochondrial counterparts. The mechanistic H(+)/e(-) stoichiometry of prot...
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In recent years, remarkable progress has been made in our understanding of the structure and function of membrane-bound proton transporters at the molecular level. Perhaps the most challenging and complex of these molecular machines are the haem–copper oxidases. These enzymes are designed to activate the kinetically stable O2 molecule, to prevent the release of potentially toxic oxygen intermed...
متن کاملRedox-driven proton pumping by heme-copper oxidases.
One of the key problems of molecular bioenergetics is the understanding of the function of redox-driven proton pumps on a molecular level. One such class of proton pumps are the heme-copper oxidases. These enzymes are integral membrane proteins in which proton translocation across the membrane is driven by electron transfer from a low-potential donor, such as, e.g. cytochrome c, to a high-poten...
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عنوان ژورنال:
- Current Biology
دوره 6 شماره
صفحات -
تاریخ انتشار 1996